Nana-suspension
應用: 新藥研發前期動物毒性
優點: 高價藥用量少，製程簡單
Noyes-Whitney equation
dC/dt = (A*D/h) (Cs-Cb)
D: diffusion coefficient
A: the available surface area of the drug particles
h: the thickness of the diffusion layer
Cs: the equilibrium solubility of the drug
Cb: the drug concentration in the medium (bulk density)
Method of Nanosuspension Preparation
| Top down method | Bottom up method | |
| Process principle | Cushing | Drug> Dissolution> molecular level (precipitation) |
| Pros | -Maintaining drug crystalline form
-Usually not using organic solvent |
Less potential contamination of processing equipment |
| Cons | -Potential contamination of processing equipment | Metastable crystalline or Amorphous
Use organic solvent |
| Process | -Ball milling
-High pressure homogenization |
-Precipitation from a drug solution in organic solvent
-Supercritical fluid |
| Utilization | Marketed products | Preclinical or clinical suppliers |
- High Pressure Homogenization
