淺談藥物奈米化技術 (Nanolizaiton)

Nana-suspension

應用: 新藥研發前期動物毒性

優點: 高價藥用量少,製程簡單

 

Noyes-Whitney equation

dC/dt = (A*D/h) (Cs-Cb)

D: diffusion coefficient

A: the available surface area of the drug particles

h: the thickness of the diffusion layer

Cs: the equilibrium solubility of the drug

Cb: the drug concentration in the medium (bulk density)

 

Method of Nanosuspension Preparation

Top down method Bottom up method
Process principle Cushing Drug> Dissolution> molecular level (precipitation)
Pros -Maintaining drug crystalline form

-Usually not using organic solvent

Less potential contamination of processing equipment
Cons -Potential contamination of processing equipment Metastable crystalline or Amorphous

Use organic solvent

Process -Ball milling

-High pressure homogenization

-Precipitation from a drug solution in organic solvent

-Supercritical fluid

Utilization Marketed products Preclinical or  clinical suppliers

 

  • High Pressure Homogenization
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